1-Chloro-2-butyne → (2S,3R,6S)4-(4-But-2-ynyloxy-benzenesulfonyl)-2,6-dimethyl-morpholine-3-carboxylic acid methyl ester

関与物質

反応手順

The title compound was prepared in a manner similar to Preparation 3 from 1-chloro-but-2-yne and 4-(4-Hydroxy-benzenesulfonyl)-2,6-dimethyl-morpholine-3-carboxylic acid methyl ester. 1HNMR (400 MHz, CDCl3): δ=7.66 (d, J=8.9 Hz, 2H), 6.98 (d, J=8.9 Hz, 2H), 4.65 (bs, 2H), 4.47 (q, J=6.4 Hz, 1H), 4.23 (s, 1H), 3.92 (m, 1H), 3.50 (s, 3H), 2.93 (dd, J=12.2 and 11.0 Hz, 1H), 1.79(t, J=2.3 Hz, 3H), 1.40 (d, J=6.6 Hz, 3H), 1.01(d, J=6.0, 3H). MS: Calculated for C18H23NO6S (M+H): 382.13. Found: 382.0.

情報源と証拠