(Phenylmethyl)hydrazine → HCID 10132921、化合物
反応式
[C:1]([C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20]([NH:27][NH2:28])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(O)=O>[CH2:20]([N:27]1[C:7]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:1]([C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=2)=[N:28]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1参加物
4
実験手順
A mixture of ethyl 4-benzoylbenzoate (13.7 g, 54 mmole), benzylhydrazine (8 g, 65 mmole), ethanole (50 mL) and HOAc (1 mL) was refluxed for 12 hours and then treated with the procedure described in Example 1 to yield a crude product that was purified by column chromatography (silica gel-benzene), and recrystallized from n-hexane to give 4.8g 1-benzyl-3-(4′-ethoxycarbonylphenyl)indazole in a yield of 25.5%.