関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phenylacetic Acid | HCID 999 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Methoxybenzaldehyde | HCID 31244 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetic Anhydride | HCID 7918 | — |
| 生成物 | 3-(4-Methoxyphenyl)-2-phenylprop-2-enoic acid | HCID 236698 | — |
反応手順
A mixture of 4-methoxybenzaldehyde (30.0 g, 0.22 mol), phenylacetic acid (31.5 g, 0.23 mol), and triethylamine (31 ml) in acetic anhydride (75 ml) was heated at 90° C. for 5 hours. After cooling, 18 ml of water was dropped carefully during 15 min. Then, potassium carbonate (243 g) in water (1800 ml) was dropped and the solution was heated at 60° C. for 1 hour. After cooling, the solution was extracted with dichloro-methane. When the aqueous phase was acidified (pH 6-7), the product was precipitated. After stirring at 0° C., the product was filtered and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06388090B2 |
|---|
| 出典データセット | uspto-grants-2002_05 |
|---|
| ORD ID | ord-ca940e1761cb445f9bcf57806700419e |
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| 出典メモ | uspto-grants-2002_05 |
|---|
