2,3-Diphenylpropionic acid → 2-Phenyl-2,3-dihydro-1H-inden-1-one

HRID 1935740

反応式

HRID 1935740 の反応式
[C:1]1([CH:7]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([OH:10])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O>[C:1]1([CH:7]2[CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:8]2=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

3

反応物 1

HCID 187442,3-Diphenylpropionic acid

生成物 1

HCID 3184912-Phenyl-2,3-dihydro-1H-inden-1-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Polyphosphoric acid (50 g) was heated in an oil bath at 140-145° C. and 2,3-diphenyl-propanoic acid (2.5 g) was added. Heating was continued for 45 min. Water was added. The mixture was cooled and extracted with ethyl acetate. The organic extracts were washed with 1 M NaOH solution and water. After drying the solvent was evaporated under reduced pressure. The product thus obtained was further purified by trituration in heptane.

後処理

  1. temperatureHeating
  2. temperatureThe mixture was cooled
  3. extractionextracted with ethyl acetate
  4. washThe organic extracts were washed with 1 M NaOH solution and water
  5. customAfter drying the solvent
  6. customwas evaporated under reduced pressure
  7. customThe product thus obtained
  8. customwas further purified by trituration in heptane

出典と根拠

ORDレコード
ord-936efe47068f487a8c3449ba258d1285
出典データセット
uspto-grants-2002_05
特許番号
US06388090B2

関連ノート

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