2-Phenyl-2,3-dihydro-1H-inden-1-one → 1-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole

HRID 1935741

反応式

HRID 1935741 の反応式
[CH2:1]([N:8]1[C:12]([CH:13]=[C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20](OC)[CH:21]=3)[CH2:16][CH:15]2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C2CC3C(=CC=CC=3)C2=O)C=CC=CC=1>>[CH2:1]([N:8]1[C:12]([CH:13]=[C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][CH:15]2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 3184912-Phenyl-2,3-dihydro-1H-inden-1-oneHCID 698324681-benzyl-5-(6-methoxy-2-phenylindan-1-ylidenemethyl)-1H-imidazole

生成物 1

HCID 698316891-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole

実験手順

1-Benzyl-5-(2-phenylindan-1-ylidenemethyl)-1H-imidazole was prepared as 1-benzyl-5-(6-methoxy-2-phenylindan-1-ylidenemethyl)-1H-imidazole above except that 2-phen-ylindan-1-one was used as a starting material. In this case after evaporation of the filtrate the residue was dissolved in diluted hydrochloric acid. The product was extracted into dichloromethane. The combined organic phases were washed with water, dried over sodium sulfate and evaporated under reduced pressure. The crude product as its hydrochloride salt was used in the next step without purification.

後処理

  1. customIn this case after evaporation of the filtrate the residue
  2. dissolutionwas dissolved in diluted hydrochloric acid
  3. extractionThe product was extracted into dichloromethane
  4. washThe combined organic phases were washed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated under reduced pressure
  7. customThe crude product as its hydrochloride salt was used in the next step without purification

出典と根拠

ORDレコード
ord-a2772c0c079b4591a42e9ac8edab933c
出典データセット
uspto-grants-2002_05
特許番号
US06388090B2

関連ノート

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