3-(2,6-Dichloro-4-trifluoromethylphenylhydrazino)propionitrile → 3-{2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazinylidene}propanenitrile

HRID 1937101ノート

反応式

HRID 1937101 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][NH:14][CH2:15][CH2:16][C:17]#[N:18]>ClC1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:9])[F:11])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][N:14]=[CH:15][CH2:16][C:17]#[N:18]

参加物

3

反応物 1

HCID 110878053-(2,6-Dichloro-4-trifluoromethylphenylhydrazino)propionitrile

生成物 1

HCID 695517003-{2-[2,6-Dichloro-4-(trifluoromethyl)phenyl]hydrazinylidene}propanenitrile

試薬・触媒・溶媒 1

HCID 7964Chlorobenzene溶媒

反応条件

温度
65 °C

実験手順

Cupric chloride (0.673 g, 2.5 equivalents) was added in one portion to a solution of 3-(2,6-dichloro-4-trifluoromethylphenylhydrazino)propionitrile (0591 g, 2 mmol) in chlorobenzene, and the mixture heated at 65° C. for 50 minutes. The reaction was judged to be complete and was cooled, washed (water), dried (magnesium sulphate), evaporated and separated by chromatography on silica gel to give 3-(2,6-dichloro-4-trifluoromethylphenylhydrazono)propionitrile,

後処理

  1. temperaturewas cooled
  2. washwashed (water)
  3. dry with materialdried (magnesium sulphate)
  4. customevaporated
  5. customseparated by chromatography on silica gel

出典と根拠

ORDレコード
ord-948b83752b024e799885ec1d1a418dae
出典データセット
uspto-grants-2002_05
特許番号
US06392081B1

反応ノート

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