1-(6-Bromonaphthalene-2-sulfonyl)piperazine → HCID 178452975、化合物

HRID 1937322

反応式

HRID 1937322 の反応式
[C:1]([O:5][C:6]([NH:8][C:9]1[NH:10][CH:11]=[C:12]([C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=O)=[CH:16][CH:15]=2)[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Br:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[CH:30]=[C:29]([S:34]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)(=[O:36])=[O:35])[CH:28]=[CH:27]2>C(O)C>[Br:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[CH:30]=[C:29]([S:34]([N:37]1[CH2:38][CH2:39][N:40]([C:18](=[O:20])[C:17]3[CH:21]=[CH:22][C:14]([C:12]4[N:13]=[C:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[NH:10][CH:11]=4)=[CH:15][CH:16]=3)[CH2:41][CH2:42]1)(=[O:35])=[O:36])[CH:28]=[CH:27]2

参加物

4

反応物 2

HCID 223297091-(6-Bromonaphthalene-2-sulfonyl)piperazineHCID 178452976HCID 178452976、化合物

生成物 1

HCID 178452975HCID 178452975、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The requisite 1-(6-bromonaphth-2-ylsulphonyl)-4-[4-(2-t-butyloxycarbonylaminoimidazol-4-yl)benzoyl]piperazine starting material was prepared by a coupling method exactly analogous to that described in Example 1, starting from 4(2-t-butyloxycarbonylaminoimidazol-4-yl)benzoic acid and 1-(6-bromonaphth-2-ylsulphonyl)piperazine, to give 1-(6-bromonaphth-2-ylsulphonyl)-4-[4-(2-t-butyloxycarbonylaminoimidazol-4-yl)benzoyl]piperazine as a colourless solid (after trituration with hot ethanol) (248 mg, 40% yield), m.p. 175-177° C., 1H NMR (d6DMSO) 1.5 ppm (s,9H), 3.0-3.1 ppm (broad s,4H), 3.4-3.7 ppm (broad s,4H), 6.6 ppm (s,2H), 7.3 ppm (d,2H), 7.4 ppm (s,1H), 7.7 ppm (d,2H), 7.8 ppm (t,2H), 8.2 ppm (t,2H), 8.4 ppm (s,1H), 8.45 ppm (s,1H); MS (M+H)+ 640/642 (w), (M+H-56)+ 584/585 (s), loss of C4H8.

後処理

  1. customThe requisite 1-(6-bromonaphth-2-ylsulphonyl)-4-[4-(2-t-butyloxycarbonylaminoimidazol-4-yl)benzoyl]piperazine starting material was prepared by a coupling method exactly analogous to

出典と根拠

ORDレコード
ord-e78264ba1e06400485a35fa465dbefa3
出典データセット
uspto-grants-2002_05
特許番号
US06395731B1

関連ノート

読み込み中…