Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol dihydrochloride

HRID 1937419

反応式

HRID 1937419 の反応式
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:4].[ClH:30]>C(O)C.C(OCC)(=O)C>[ClH:30].[ClH:30].[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH3:4]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 54071300HCID 54071300、化合物

生成物 1

HCID 119720442-(Piperazin-1-yl)propan-1-ol dihydrochloride収率 89%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

1-(1-Hydroxy-2-propyl)-2-triphenylmethylpiperazine (1.69 g) obtained in step 2 was dissolved in ethanol (20 ml), and a 4 mol/l hydrogen chloride solution in ethyl acetate (10 ml) was dropwise added thereto. The mixture was stirred at room temperature for 10 minutes. The solvent was distilled off under reduced pressure, the residue was suspended in ethyl ether, and the precipitated crystals were collected by filtration to give Compound L (840 mg, 89%).

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-c8601b29fb4040a69dddd3603f032fcd
出典データセット
uspto-grants-2002_05
特許番号
US06395738B1

関連ノート

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