化工社化工社 化学情報印刷レポート · 研究参考用
2-Chloropyridine → (R)-N-(2-pyridyl)-2-aminopropanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloropyridine | HCID 7977 | — |
| 反応物 | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (R)-N-(2-pyridyl)-2-aminopropanol | HCID 21339422 | 87.4% |
反応手順
(R)-Alaninol (107.3 g, 1.43M) was added dropwise with stirring to a solution of potassium tertiary butoxide (160 g, 1.43M) in tetrahydrofuran (1L). After the exothermic reaction had cooled to room termperature, 2-chloropyridine (162.4 g, 1.43M) was added dropwise. The reaction mixture was heated under reflux overnight, cooled, filtered and evaporated to an oil. The oil was dissolved in xylene (1,5L) and toluene-p-sulphonic acid (0.5 g) was added. The mixture was heated under reflux overnight. On cooling to room temperature the product crystallised to give (R)-N-(2-pyridyl)-2-aminopropanol (190 g), [α]D26=30° (c=1 in CHCl3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06395902B1 |
| 出典データセット | uspto-grants-2002_05 |
| ORD ID | ord-567d0f352f694ca785f48c23cb95f136 |
| 出典メモ | uspto-grants-2002_05 |