3-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline → 3-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

HRID 1938336ノート

反応式

HRID 1938336 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:24])[F:23])[CH:8]=2)([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[C:9]([O:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[C:22]([F:25])([F:23])[F:24])[CH:8]=2

参加物

4

反応物 1

HCID 214693273-Nitro-7-(2-trifluoromethylbenzyloxy)quinoline

生成物 1

HCID 214693313-Amino-7-(2-trifluoromethylbenzyloxy)quinoline

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

In ethanol (30 mL) was suspended 3-nitro-7-(2-trifluoromethylbenzyloxy)quinoline (600 mg, 1.72 mmol.), and to the suspension was added platinum oxide (72 mg). Then, catalytic reduction was performed for 3 hours. After the completion of reaction was confirmed, the reaction mixture was filtered over Celite®, and the filtrate was placed under reduced pressure to leave the desired compound as brown oil in the quantitative yield.

後処理

  1. customAfter the completion of reaction
  2. filtrationthe reaction mixture was filtered over Celite®

出典と根拠

ORDレコード
ord-ec5422ec689e43a8bdbf528a60d38702
出典データセット
uspto-grants-1997_12
特許番号
US05693651

反応ノート

読み込み中…