Sodium Acetate → 5-[[7-[(5-Ethyl-2-pyridinyl)methoxy]quinolin-3-yl]methyl]-2-imino-1,3-thiazolidin-4-one

HRID 1938346ノート

反応式

HRID 1938346 の反応式
Br[CH:2]([CH2:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH3:27])=[CH:22][N:21]=1)[CH:12]=2)[C:3]([O:5]C)=O.[NH2:28][C:29]([NH2:31])=[S:30].C([O-])(=O)C.[Na+]>C(O)C>[CH2:26]([C:23]1[CH:24]=[CH:25][C:20]([CH2:19][O:18][C:13]2[CH:12]=[C:11]3[C:16]([CH:17]=[C:8]([CH2:7][CH:2]4[S:30][C:29](=[NH:28])[NH:31][C:3]4=[O:5])[CH:9]=[N:10]3)=[CH:15][CH:14]=2)=[N:21][CH:22]=1)[CH3:27]

参加物

5

反応物 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 21469288Methyl 2-bromo-3-[7-(5-ethyl-2-pyridylmethoxy)-3-quinolyl]propionate

生成物 1

HCID 1415769645-[[7-[(5-Ethyl-2-pyridinyl)methoxy]quinolin-3-yl]methyl]-2-imino-1,3-thiazolidin-4-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (20 mL) was dissolved the crude residue (790 mg) of methyl 2-bromo-3-[7-(5-ethyl-2-pyridylmethoxy)-3-quinolyl]propionate. The solution was heated under reflux for 15 hours after addition of thiourea (140 mg, 1.84 mmol.) and sodium acetate (150 mg, 1.84 mmol.). After the completion of reaction was confirmed, ethanol was distilled off. To the residue were added ethyl acetate and aqueous sodium hydrogen carbonate. The organic portion was recovered, washed with water, and dried over sodium sulfate.

後処理

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 15 hours
  3. customAfter the completion of reaction
  4. distillationethanol was distilled off
  5. additionTo the residue were added ethyl acetate and aqueous sodium hydrogen carbonate
  6. customThe organic portion was recovered
  7. washwashed with water
  8. dry with materialdried over sodium sulfate

出典と根拠

ORDレコード
ord-b4c2325227fb431a821ce6554d1a385d
出典データセット
uspto-grants-1997_12
特許番号
US05693651

反応ノート

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