Ethyl 4,4,4-trifluoro-3-oxo-2-phenylbutanoate → 6-Trifluoromethyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1939147ノート

反応式

HRID 1939147 の反応式
[F:1][C:2]([F:18])([F:17])[C:3]([CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]CC)=O)=[O:4].[CH2:19]=[N:20][C:21]([CH3:31])([C:23]1[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([Cl:30])[CH:24]=1)[CH3:22]>C1(C)C(C)=CC=CC=1>[F:18][C:2]([F:1])([F:17])[C:3]1[O:4][CH2:19][N:20]([C:21]([CH3:31])([C:23]2[CH:24]=[C:25]([Cl:30])[CH:26]=[C:27]([Cl:29])[CH:28]=2)[CH3:22])[C:6](=[O:8])[C:5]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 13913997Ethyl 4,4,4-trifluoro-3-oxo-2-phenylbutanoateHCID 21223286N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

生成物 1

HCID 212232766-Trifluoromethyl-3-[1-methyl-1-(3,5-dichlorophenyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one収率 84%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

Ethyl 2-trifluoroacetyl-2-phenylacetate (1.30 g) and N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine (1.19 g) were mixed, and xylene (10 ml) was added thereto. The mixture was allowed to react by refluxing for 30 minutes. The solvent was removed by evaporation, and the crude product was recrystallized from a mixture of hexane and ethyl acetate to afford the captioned compound (1.80 g, yield 84%).

後処理

  1. customto react
  2. temperatureby refluxing for 30 minutes
  3. customThe solvent was removed by evaporation
  4. customthe crude product was recrystallized from a mixture of hexane and ethyl acetate

出典と根拠

ORDレコード
ord-23118503df7048059f2b101b339f46a4
出典データセット
uspto-grants-1997_12
特許番号
US05696054

反応ノート

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