Hydrochloric Acid → 9-Carboisopropoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one

HRID 1939628ノート

反応式

HRID 1939628 の反応式
Cl.[C:2]([CH:7]1[CH2:16][CH2:15][C:14]2[NH:13][C:12](=[O:17])[N:11]3[CH:18]=[C:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[F:27])[N:20]=[C:10]3[C:9]=2[CH2:8]1)([O:4][CH2:5][CH3:6])=[O:3].[CH3:28]C(O)C>>[C:2]([CH:7]1[CH2:16][CH2:15][C:14]2[NH:13][C:12](=[O:17])[N:11]3[CH:18]=[C:19]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[F:27])[N:20]=[C:10]3[C:9]=2[CH2:8]1)([O:4][CH:5]([CH3:28])[CH3:6])=[O:3]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 99285709-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one

生成物 1

HCID 154342799-Carboisopropoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one

反応条件

温度
150 °C

実験手順

To 10 mL of 2-propanol saturated with HCl gas was added 9-Carboethoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazolin-5(6H)-one (100 mg) and the mixture was heated in a sealed tube at 150° C. for 1 h. The reaction was cooled and the solvent was evaporated in vacuo. To the reaction mixture was added 10 mL of H2O and the mixture was then brought to pH 7 with ammonium hydroxide. The solid was collected and dried to yield 9-Carboisopropoxy-2-(2-fluorophenyl)-7,8,9,10-tetrahydroimidazo[1,2-c]-quinazolin-5(6H)-one (Compound 14), m.p. 282°-285° C.

後処理

  1. temperatureThe reaction was cooled
  2. customthe solvent was evaporated in vacuo
  3. additionTo the reaction mixture was added 10 mL of H2O
  4. customThe solid was collected
  5. customdried

出典と根拠

ORDレコード
ord-f4ccc1e0d3a6425ba90b174f6990ae69
出典データセット
uspto-grants-1997_12
特許番号
US05696260

反応ノート

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