Water → (+)-2-Octanol
反応式
[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]CCCC(OC)=O)(OC)=O.[OH2:19]>>[CH3:1][C@H:5]([OH:19])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]参加物
3
実験手順
Interesterification was carried out in the same manner as in Example 9, except for replacing dimethyl tetradecadicarboxylate with 140 g of dimethyl decamethylenedicarboxylate at 80° C. for 25 hours. The water content of the reaction system was 0.04% by weight, and 95% of the lipase particles had a particle size of 20 to 60 μm. Gas chromatography of the reaction mixture revealed that 58 mol % of (R,S)-2-octanol had been converted to its decamethylenedicarboxylic acid ester. The reaction mixture was treated in the same manner as in Example 9 to remove lipase, and the filtrate was subjected to simple distillation at 95° C. and 3 mmHg. However, it was impossible to isolate (S)-(-)-2-octanol with high purity due to co-distillation of other components.
後処理
- customat 80° C.
- customfor 25 hours
- additionThe reaction mixture was treated in the same manner as in Example 9
- customto remove lipase
- distillation