Water → 1-Phenylethanol, (S)-

Interesterification was carried out in the same manner as in Example 12, except for replacing dimethyl octadecadicarboxylate with 150 g of dimethyl sebacate at 90° C. for 30 hours. The water content of the reaction system was 0.07% by weight, and 87% of the lipase particles had a particle size of 25 to 60 μm. After completion of the reaction, gas chromatography of the reaction mixture revealed that 42 mol % of (R,S)-1-phenylethanol had been converted to its sebacic acid ester. The reaction mixture was treated in the same manner as in Example 12 to remove lipase, and the filtrate was subjected to simple distillation at 90° C. and 3 mmHg. However, it was impossible to isolate (S)-(-)-1-phenylethanol due to co-distillation of other components, such as esters.

1. customat 90° C.
2. customfor 30 hours
3. customAfter completion of the reaction, gas chromatography of the reaction mixture
4. additionThe reaction mixture was treated in the same manner as in Example 12
5. customto remove lipase
6. distillationthe filtrate was subjected to simple distillation at 90° C.

ORDレコード

ord-2b366acb98994216a705d90a1e2ed002

出典データセット

uspto-grants-1997_12

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05696299