4,4-Diethoxybutylamine → HCID 70270548、化合物

HRID 1939853

反応式

HRID 1939853 の反応式
[CH2:1]([O:3][CH:4]([O:9][CH2:10][CH3:11])[CH2:5][CH2:6][CH2:7][NH2:8])[CH3:2].[S:12](Cl)([OH:15])(=O)=[O:13].[CH:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:10]([O:9][CH:4]([O:3][CH2:1][CH3:2])[CH2:5][CH2:6][CH2:7][NH:8][S:12]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:15])=[O:13])[CH3:11]

参加物

3

反応物 2

HCID 806724,4-DiethoxybutylamineHCID 22564087Benzene sulphochloride

生成物 1

HCID 70270548HCID 70270548、化合物収率 86%

実験手順

42 g 4-amino butyraldehyde diethyl acetal and 88 g benzene sulfochloride are processed as explained in Preparation Example 1. The reaction mixture is not clear from the very beginning and vigorous stirring is therefore indispensable. Methylene chloride is used for the extraction of the sulfonamide acetal. Yield: 86% based on the amino acetal used. The product will crystallize when standing for an extended time at room temperature; melting point: 109°-111°° C.; for further purification recrystallization from a 2:1 volume mixture of water and ethanol is possible.

後処理

  1. customas explained in Preparation Example 1
  2. extractionMethylene chloride is used for the extraction of the sulfonamide acetal
  3. customThe product will crystallize when
  4. customstanding for an extended time at room temperature
  5. customfor further purification recrystallization
  6. additionfrom a 2:1 volume mixture of water and ethanol

出典と根拠

ORDレコード
ord-f479b9f1c492412d8f65bb6cdc580c4f
出典データセット
uspto-grants-1997_12
特許番号
US05698360

関連ノート

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