2-(6-(Cyanomethyl)pyridin-2-yl)acetonitrile → HCID 12131338、化合物

HRID 1939874ノート

反応式

HRID 1939874 の反応式
[C:1]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][C:11]#[N:12])[N:5]=1)#[N:2]>CO.[Ni]>[NH2:2][CH2:1][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][CH2:11][NH2:12])[N:5]=1

参加物

4

反応物 1

HCID 5826922-(6-(Cyanomethyl)pyridin-2-yl)acetonitrile

生成物 1

HCID 12131338HCID 12131338、化合物収率 83%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

To a solution of 2,6-bis(cyanomethyl)pyridine (4.3 g, 27 mmol) in methanol (75 ml, saturated with ammonia) was added Raney nickel (10.0 g, excess) and the mixture hydrogenated at 45 psi and room temperature for 48 hours. The catalyst was filtered off and the solvent evaporated in vacuo to give 2,6-bis(2-aminoethyl)pyridine as a brown viscous oil (3.7 g, 83%). This was used without further purification.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-1ed6c26f3d85450ebdb7a193f29c0e46
出典データセット
uspto-grants-1997_12
特許番号
US05698546

反応ノート

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