化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 2-Benzylpropane-1,3-diol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Diethyl 2-benzylpropanedioate | HCID 69090 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-Benzylpropane-1,3-diol | HCID 520241 | 63.6% |
反応手順
Slowly add a solution of diethyl 2-benzylmalonate (20 g) in Et2O (300 mL) to a slurry of LiAlH4 (6 g) in Et2O (300 mL), then heat the reaction mixture at reflux for 14 h. Carefully add 4N NaOH to the reaction mixture until there is no precipitate, then extract with EtOAc. Concentrate the organic layer and purify the crude product on a silica gel column, eluting with EtOAc to obtain 2-benzyl-1,3-propanediol (8.45 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05698548 |
| 出典データセット | uspto-grants-1997_12 |
| ORD ID | ord-88bac1799d3a4ae4a0f6d84a9b4445e2 |
| 出典メモ | uspto-grants-1997_12 |