1-(4-Methoxyphenyl)-1-methylethyl azide → 2-(4-Methoxyphenyl)propan-2-amine

HRID 1940426ノート

反応式

HRID 1940426 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([N:12]=[N+]=[N-])([CH3:11])[CH3:10])=[CH:5][CH:4]=1.[H][H]>CO.[Pt]=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:5][CH:4]=1

参加物

5

反応物 2

HCID 156972291-(4-Methoxyphenyl)-1-methylethyl azideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 110082782-(4-Methoxyphenyl)propan-2-amine収率 95%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

1.58 g of platinum oxide were added to a solution of 21.0 g of 1-(4-methoxyphenyl)-1-methylethyl azide [prepared as described in step (a) above] in 100 ml of methanol. The reaction mixture was then stirred for 5 hours under a stream of hydrogen. At the end of this time, the mixture was filtered, diluted with methylene chloride, and washed with an aqueous solution of sodium hydrogencarbonate, with water and with a saturated aqueous solution of sodium chloride, in that order. It was then dried over anhydrous magnesium sulfate, and concentrated by evaporation under reduced pressure, to give 17.2 g (yield 95%) of the title compound.

後処理

  1. filtrationAt the end of this time, the mixture was filtered
  2. additiondiluted with methylene chloride
  3. washwashed with an aqueous solution of sodium hydrogencarbonate, with water and with a saturated aqueous solution of sodium chloride, in that order
  4. dry with materialIt was then dried over anhydrous magnesium sulfate
  5. concentrationconcentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-1dfccbeb4e4f47af85ed2b98139b0cab
出典データセット
uspto-grants-1997_12
特許番号
US05698720

反応ノート

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