Hydrochloric Acid → 1-(2,3-Dihydro-7-benzofuranyl)ethanone

HRID 1940596ノート

反応式

HRID 1940596 の反応式
[O:1]1[C:5]2[C:6]([C:10]([OH:12])=O)=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.[CH3:13][Li].Cl>C(OCC)C>[C:10]([C:6]1[C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=[CH:8][CH:7]=1)(=[O:12])[CH3:13]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 27950142,3-Dihydro-1-benzofuran-7-carboxylic acidHCID 178418348HCID 178418348、化合物

生成物 1

HCID 106070731-(2,3-Dihydro-7-benzofuranyl)ethanone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a cooled suspension of 2,3-dihydrobenzofuran-7-carboxylic acid (D1) (2 g) in dry diethyl ether (100 ml) was added dropwise under argon, methyllithium (16.2 ml of a 1.5M solution in diethyl ether). The mixture was stirred at room temperature for 18 h, added to 5N hydrochloric acid (50 ml) and extracted into ethyl acetate. The organic phase was washed with potassium carbonate, then water and dried (Na2SO4). The solvent was evaporated under reduced pressure to leave the title compound as a plate lemon solid (1.5 g, 76%)

後処理

  1. additionwas added dropwise under argon
  2. extractionextracted into ethyl acetate
  3. washThe organic phase was washed with potassium carbonate
  4. dry with materialwater and dried (Na2SO4)
  5. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-68ff1040be2647289c7f4d896aa4538a
出典データセット
uspto-grants-1997_12
特許番号
US05700818

反応ノート

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