Diethyl Ether → [4-(Chloromethyl)-1,3-thiazol-2-yl]methanol hydrochloride
反応式
C([O:4][CH2:5][C:6]1[S:7][CH2:8][C:9]([CH2:12][Cl:13])(O)[N:10]=1)(=O)C.C(OCC)C>Cl.C(O)(C)C>[ClH:13].[Cl:13][CH2:12][C:9]1[N:10]=[C:6]([CH2:5][OH:4])[S:7][CH:8]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
7.48 g of 2-acetoxymethyl-4-chloromethyl-4-hydroxy-thiazoline, prepared according to either Example 3 or 4, was suspended in 20 ml of 5N hydrogen chloride in isopropanol and heated to reflux for 45 minutes. The suspension was cooled in an ice bath and 30 ml of diethyl ether added dropwise over 30 minutes. The slurry was stirred a further 30 minutes at 0° C. and the precipitate filtered, washed with ether and dried under vacuum. 4-chloromethyl-2-hydroxymethylthiazole hydrochloride, 6.22 g (93% yield) was obtained.
後処理
- temperatureheated
- temperatureto reflux for 45 minutes
- temperatureThe suspension was cooled in an ice bath
- filtrationthe precipitate filtered
- washwashed with ether
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-de57cedc9da74d3ebeb87a957a9a593f
- 出典データセット
- uspto-grants-1997_12
- 特許番号
- US05700945
反応ノート
読み込み中…