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Thionyl Chloride → 4,4-Dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4,4-Dimethyl-2-(4'hydroxymethylbiphenyl-2-yl)oxazoline | HCID 11065876 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4,4-Dimethyl-2-(4'-chloromethylbiphenyl-2-yl)oxazoline | HCID 10979477 | 98.7% |
反応手順
1.0 g (3.55 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline was dissolved in methylene chloride (15 ml). Under cooling with ice. 0.51 g (4.29 mmol) of thionyl chloride was dropwise added thereto, followed by stirring for one hour. The reaction liquid was poured into an aqueous solution of sodium hydrogencarbonate, followed by the extraction with methylene chloride. After washing with water and drying, vacuum concentration was conducted. 1.05 g of the title compound was obtained as a crystal (yield 99%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05700938 |
| 出典データセット | uspto-grants-1997_12 |
| ORD ID | ord-328be71ed94c4955b385d16c611a3962 |
| 出典メモ | uspto-grants-1997_12 |