Hydrochloric Acid → 4-[(Benzylamino)methyl]benzonitrile

HRID 1941099ノート

反応式

HRID 1941099 の反応式
C([C:8](=[N:17]O)[C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.Cl>C(O)C>[CH2:8]([NH:17][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]#[N:14])=[CH:15][CH:16]=1)[C:9]1[CH:16]=[CH:15][CH:12]=[CH:11][CH:10]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86751769HCID 86751769、化合物

生成物 1

HCID 123291374-[(Benzylamino)methyl]benzonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3.44 g (15 mmol) of 4-(benzyloximinomethyl)benzonitrile in 120 ml of ethanol are cooled to -15° C. 4.46 g (48 mmol, 4.85 ml) of borane-pyridine complex are then added dropwise in the course of 10 minutes and then 26 ml of ethanolic HCl solution in the course of 20 minutes. After stirring at room temperature for 24 h, the resulting solid is filtered off, dissolved in dichloromethane and the solution is washed with water and sodium hydrogen carbonate solution. The organic phase is dried and concentrated in vacuo.

後処理

  1. addition4.46 g (48 mmol, 4.85 ml) of borane-pyridine complex are then added dropwise in the course of 10 minutes
  2. customin the course of 20 minutes
  3. filtrationthe resulting solid is filtered off
  4. dissolutiondissolved in dichloromethane
  5. washthe solution is washed with water and sodium hydrogen carbonate solution
  6. customThe organic phase is dried
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-bb0550b839ee43c0a9551859d23e1f80
出典データセット
uspto-grants-1997_12
特許番号
US05703050

反応ノート

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