Trichloroacetyl chloride → 2,2,2-Trichloro-1-morpholin-4-ylethanone
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[Cl:13][C:14]([Cl:19])([Cl:18])[C:15](Cl)=[O:16]>CCOC(C)=O>[Cl:13][C:14]([Cl:19])([Cl:18])[C:15]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:16]参加物
5
実験手順
Morpholine (4.0 mL, 45 mmol) is dissolved in EtOAc (50 mL) and saturated K2CO3 (40 mL) added. The mixture is cooled in an ice bath and trichloroacetyl chloride (5.0 mL, 45 mmol) added drop-wise. The reaction is stirred for 20 min then diluted with EtOAc (200 mL) and washed with aq. K2CO3 (20 mL), water (2×50 mL) and brine (30 mL). The organic layer is dried over MgSO4. Rotary evaporation gives trichloroacetylmorpholine.
後処理
- temperatureThe mixture is cooled in an ice bath
- washwashed with aq. K2CO3 (20 mL), water (2×50 mL) and brine (30 mL)
- dry with materialThe organic layer is dried over MgSO4
- customRotary evaporation
出典と根拠
- ORDレコード
- ord-5b24642c9cda4212a92327a9f47a5809
- 出典データセット
- uspto-grants-1997_12
- 特許番号
- US05703075
反応ノート
読み込み中…