Benzaldehyde → P,P-Diphenyl-N-(phenylmethylene)phosphinic amide

HRID 1941483

反応式

HRID 1941483 の反応式
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]1([P:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:17])[NH2:16])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N(CC)CC)C>ClCCl.[Ti](Cl)(Cl)(Cl)Cl>[C:9]1([P:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)(=[O:17])[N:16]=[CH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

6

反応物 3

HCID 240BenzaldehydeHCID 8471TriethylamineHCID 853560Diphenylphosphinamide

生成物 1

HCID 608413P,P-Diphenyl-N-(phenylmethylene)phosphinic amide収率 40%

試薬・触媒・溶媒 2

HCID 24193Titanium Tetrachloride触媒HCID 6344Dichloromethane溶媒2 回

反応条件

温度
0 °C

実験手順

P,P-diphenyl-N-phenylmethylene phosphinic amide was prepared following the method of Jennings (ibid) by adding titanium tetrachloride (635 ml; 5.78 mmol) in dry dichloromethane (10 ml) to a stirred solution of benzaldehyde (1.17 ml; 11.59 mmol), P,P-diphenylphosphinic amide (2.52 g; 11.59 mmol) and anhydrous triethylamine (4.84 ml; 34.78 mmol) in dry dichloromethane (50 ml) at 0° C. Upon completion of the addition, the stirring was maintained at 0° C. for a further 4 hours. Subsequent work-up gave P,P-diphenyl-N-phenylmethylene phosphinic amide (1.4 g; 40%).

後処理

  1. customP,P-diphenyl-N-phenylmethylene phosphinic amide was prepared
  2. additionUpon completion of the addition

出典と根拠

ORDレコード
ord-b61ac70fc6c24d4ebf0ab98b7bfc3d55
出典データセット
uspto-grants-1997_12
特許番号
US05703246

関連ノート

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