Hydrochloric Acid → HCID 67503622、化合物

HRID 19415

反応式

HRID 19415 の反応式
C(OC(=O)[NH:7][CH:8]([C:16](=[O:28])[NH:17][C:18]1[CH:22]=[CH:21][N:20]([CH2:23][C:24]([OH:27])([CH3:26])[CH3:25])[N:19]=1)[CH2:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)(C)(C)C.[ClH:30]>CO>[ClH:30].[NH2:7][CH:8]([CH2:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[C:16]([NH:17][C:18]1[CH:22]=[CH:21][N:20]([CH2:23][C:24]([OH:27])([CH3:25])[CH3:26])[N:19]=1)=[O:28]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66898741[1-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-ylcarbamoyl]-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid t-butyl ester

生成物 1

HCID 67503622HCID 67503622、化合物収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of [1-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-ylcarbamoyl]-2-(tetrahydro-pyran-4-yl)-ethyl]-carbamic acid t-butyl ester (3.2 g, 7.8 mmol) in methanol (150 mL) was treated with hydrogen chloride gas for 2 min at 0° C. and then stirred at room temperature for 1 h. After this time the mixture was concentrated in vacuo and the residue treated with acetonitrile (50 mL). The mixture was concentrated in vacuo which afforded 2-amino-N-[1-(2-hydroxy-2-methyl-propyl)-1H-pyrazol-3-yl]-3-(tetrahydro-pyran-4-yl)-propionamide hydrochloride (3.0 g, 100%) as a white solid.

後処理

  1. concentrationAfter this time the mixture was concentrated in vacuo
  2. additionthe residue treated with acetonitrile (50 mL)
  3. concentrationThe mixture was concentrated in vacuo which

出典と根拠

ORDレコード
ord-9a703a7a4178498f8c275dbd4a58d637
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

関連ノート

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