HCID 57475884、化合物 → HCID 67234255、化合物
反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([F:18])=[C:6]([C@:8]2([CH3:17])[C:13]([F:15])([F:14])[CH2:12][O:11][C:10]([NH2:16])=[N:9]2)[CH:7]=1.[F:19][CH2:20][C:21]1[O:22][CH:23]=[C:24]([C:26]([OH:28])=[O:27])[N:25]=1>>[CH:26]([OH:28])=[O:27].[NH2:16][C:10]1[O:11][CH2:12][C:13]([F:14])([F:15])[C@:8]([C:6]2[CH:7]=[C:2]([NH:1][C:26]([C:24]3[N:25]=[C:21]([CH2:20][F:19])[O:22][CH:23]=3)=[O:27])[CH:3]=[CH:4][C:5]=2[F:18])([CH3:17])[N:9]=1参加物
3
実験手順
The condensation of (R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (intermediate XI-1) and 2-fluoromethyl-oxazole-4-carboxylic acid following procedure I yielded the title compound after purification by preparative HPLC as a white solid. MS (ISP): m/z=387.1 [M+H]+.
出典と根拠
- ORDレコード
- ord-60380b0340854ad890610704eb1ffaf4
- 出典データセット
- uspto-grants-2013_03
- 特許番号