Hydrochloric Acid → Methyl 2-amino-5-bromo-3-nitrobenzoate

HRID 1941948ノート

反応式

HRID 1941948 の反応式
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:5]=1[NH:14]C(=O)C(F)(F)F.Cl>CO>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([N+:11]([O-:13])=[O:12])[C:5]=1[NH2:14]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 59337630HCID 59337630、化合物

生成物 1

HCID 17984898Methyl 2-amino-5-bromo-3-nitrobenzoate収率 84.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
80 °C

実験手順

A stirred suspension of 5-Bromo-3-nitro-2-(2,2,2-trifluoro-acetylamino)-benzoic acid methyl ester (8 g, 21.56 mmol) in methanol (150 ml) was treated with hydrochloric acid (6M, 75 ml) and heated at 80° C. for 16 h. After cooling to ambient temperature, the yellow solid was collected by filtration and washed with cold water and dried in vacuo to give 2-Amino-5-bromo-3-nitro-benzoic acid methyl ester (5.0 g, 84%).

後処理

  1. temperatureAfter cooling to ambient temperature
  2. filtrationthe yellow solid was collected by filtration
  3. washwashed with cold water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-e6e8295877a448dca6b37ba36c27fa20
出典データセット
uspto-grants-2013_03
特許番号
US08389516B2

反応ノート

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