Hydrochloric Acid → 2-[6-(3-Hydroxyazetidin-1-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

HRID 1942038ノート

反応式

HRID 1942038 の反応式
[ClH:1].[OH:2][CH:3]1[CH2:6][N:5]([C:7]2[N:12]=[CH:11][N:10]=[C:9]([N:13]3[C:17](=[O:18])[C:16]([N:19]4[CH:23]=[CH:22][N:21]=[N:20]4)=[CH:15][NH:14]3)[CH:8]=2)[CH2:4]1>O1CCOCC1>[ClH:1].[OH:2][CH:3]1[CH2:4][N:5]([C:7]2[N:12]=[CH:11][N:10]=[C:9]([N:13]3[C:17](=[O:18])[C:16]([N:19]4[CH:23]=[CH:22][N:21]=[N:20]4)=[CH:15][NH:14]3)[CH:8]=2)[CH2:6]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 596036202-[6-(3-Hydroxyazetidin-1-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

生成物 1

HCID 674573592-[6-(3-Hydroxyazetidin-1-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3 ml of a 4 N solution of hydrogen chloride in dioxane are added to 105 mg (0.4 mmol) of the compound from Example 88 and the mixture is stirred at RT for 1 h. The solid is filtered off, washed with tert-butyl methyl ether and dried under a high vacuum.

後処理

  1. filtrationThe solid is filtered off
  2. washwashed with tert-butyl methyl ether
  3. customdried under a high vacuum

出典と根拠

ORDレコード
ord-7f7a53b81e9a4dcc9efed753ab468e2c
出典データセット
uspto-grants-2013_03
特許番号
US08389520B2

反応ノート

読み込み中…