1,3-Diethyl 2-oxopropanedioate → HCID 68476438、化合物

HRID 1942135ノート

反応式

HRID 1942135 の反応式
[NH2:1][C:2]1[C:3]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.O=[C:16]([C:22](OCC)=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>C(O)C>[O:23]=[C:22]1[N:8]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:3]2[N:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:16]1[C:17]([O:19][CH2:20][CH3:21])=[O:18]

参加物

4

反応物 2

HCID 691051,3-Diethyl 2-oxopropanedioateHCID 106790912-N-phenylpyridine-2,3-diamine

生成物 1

HCID 68476438HCID 68476438、化合物収率 58%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

11.68 g (63 mmol) of 3-amino-2-anilinopyridine was dissolved in ethanol (150 mL), and 12.07 g (69 mmol) of diethyl ketomalonate was added thereto. The mixture was heated to reflux for 4 hours while stirring. After confirming the completion of the reaction, the reaction solution was cooled to room temperature, and the solvent was distilled off under reduced pressure. The residue thus obtained was washed using diisopropyl ether, to obtain 10.74 g (yield: 58%) of ethyl 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate as pale yellow crystals.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 4 hours
  3. customthe completion of the reaction
  4. distillationthe solvent was distilled off under reduced pressure
  5. customThe residue thus obtained
  6. washwas washed

出典と根拠

ORDレコード
ord-4adfd40748164249b3bdbde6abb660c9
出典データセット
uspto-grants-2013_03
特許番号
US08389523B2

反応ノート

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