Hydrochloric Acid → 3-Oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid

HRID 1942136ノート

反応式

HRID 1942136 の反応式
[O:1]=[C:2]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:6]2[N:14]=[CH:15][CH:16]=[CH:17][C:5]=2[N:4]=[C:3]1[C:18]([O:20]CC)=[O:19].Cl>C(O)(=O)C>[O:1]=[C:2]1[N:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:6]2[N:14]=[CH:15][CH:16]=[CH:17][C:5]=2[N:4]=[C:3]1[C:18]([OH:20])=[O:19]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68476438HCID 68476438、化合物

生成物 1

HCID 675319973-Oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid収率 67.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

10.74 g (36 mmol) of ethyl 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate was dissolved in acetic acid (270 mL), and 6 N hydrochloric acid (80 mL) was added thereto at room temperature. Then, the mixture was stirred overnight at room temperature. After confirming the completion of the reaction, the solvent was distilled off under reduced pressure, and water (100 mL) was added. The solid thus obtained was separated by filtration and dried, to obtain 6.50 g (yield: 67%) of 3-oxo-4-phenyl-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylic acid as pale brown crystals.

後処理

  1. customat room temperature
  2. customthe completion of the reaction
  3. distillationthe solvent was distilled off under reduced pressure, and water (100 mL)
  4. additionwas added
  5. customThe solid thus obtained
  6. customwas separated by filtration
  7. customdried

出典と根拠

ORDレコード
ord-64d48a0cda3748a48766773d50c82dc2
出典データセット
uspto-grants-2013_03
特許番号
US08389523B2

反応ノート

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