3-Methyl-3-oxetanemethanol → 2-(3-Methyl-oxetan-3-ylmethoxy)-5-phenylethynyl-pyrimidine
反応式
CS([C:5]1[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][N:6]=1)(=O)=O.[CH3:19][C:20]1([CH2:24][OH:25])[CH2:23][O:22][CH2:21]1>>[CH3:19][C:20]1([CH2:24][O:25][C:5]2[N:10]=[CH:9][C:8]([C:11]#[C:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[CH:7][N:6]=2)[CH2:23][O:22][CH2:21]1参加物
3
実験手順
The title compound, yellow solid, MS: m/e=281.1 (M+H+), can be prepared in accordance with the general method of example 1, step 3 from 2-methanesulfonyl-5-phenylethynyl-pyrimidine (example 1, step 2) and (3-methyl-oxetan-3-yl)-methanol by using Cs2CO3 as base and dioxane as solvent for 16 hours at 100° C.
出典と根拠
- ORDレコード
- ord-3be123aed1ef4c68b756145d5660fb25
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389536B2
反応ノート
読み込み中…