Phenylacetylene → rac-1-(5-Phenylethynyl-pyridin-2-yl)-ethanol

反応式

Br[C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:10])[CH3:9])=[N:6][CH:7]=1.[C:11]1([C:17]#[CH:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[C:11]1([C:17]#[C:18][C:2]2[CH:3]=[CH:4][C:5]([CH:8]([OH:10])[CH3:9])=[N:6][CH:7]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

反応物 2

HCID 10821Phenylacetylene

HCID 426142881-(5-Bromopyridin-2-yl)ethanol

生成物 1

HCID 57517078rac-1-(5-Phenylethynyl-pyridin-2-yl)-ethanol

実験手順

The title compound, brown solid, MS: m/e=224.2 (M+H+), can be prepared in accordance with the general method of example 31, step 1 from rac-1-(5-bromopyridin-2-yl)ethanol and phenylacetylene.

出典と根拠

ORDレコード: ord-8fd5f4887038469598acb5ffbbec10f7
出典データセット: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08389536B2

反応ノート

読み込み中…