化工社化工社 化学情報印刷レポート · 研究参考用
Naltrexone Base → Benzyl Alcohol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Naltrexone Base | HCID 21159611 | — |
| 溶媒 | Benzyl Alcohol | HCID 244 | — |
| 生成物 | Benzyl Alcohol | HCID 244 | 70% |
| 生成物 | 3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one | HCID 4428 | 30% |
反応手順
A 1 kg batch of naltrexone microspheres were prepared as follows. Polymer solution was formed by dissolving 75:25 DL PLGA (poly(lactide)-co-glycolide) in ethyl acetate (EtAc) to form a solution of 16.7% polymer and 83.3% EtAc. A naltrexone solution was formed by dissolving naltrexone base in benzyl alcohol (BA) to form a solution of 30% naltrexone base anhydrous and 70% BA. The polymer solution and the naltrexone solution were mixed together to form a drug/polymer solution that was the “organic” or “oil” phase of the emulsion.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08389540B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-87e7e389865e429790b5077a8a93d144 |
| 出典メモ | uspto-grants-2013_03 |