Acetic Acid → Cyclohexanecarboxylic acid (4-oxo-butyl)-amide
反応式
C([O:3][CH:4](OCC)[CH2:5][CH2:6][CH2:7][NH:8][C:9]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10])C.C(O)(=O)C.Cl>C(O)C>[O:3]=[CH:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([CH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:10]参加物
5
実験手順
1.09 g (4 mmol) 20A, 5 mL acetic acid, 2.5 mL 1N aqueous hydrochloric acid and 20 mL ethanol are put together and stirred for 16 hours under argon atmosphere. Ethanol is evaporated. Then the resulting residue is dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase is dried with sodium sulfate and the solvent evaporated in vacuum. The crude product is obtained in almost quantitative yield.
後処理
- customEthanol is evaporated
- additionThen the resulting residue is dispersed in dichloromethane
- extractionextracted with saturated sodium bicarbonate solution
- dry with materialThe organic phase is dried with sodium sulfate
- customthe solvent evaporated in vacuum
出典と根拠
- ORDレコード
- ord-39c617570c8b42f4a0ef98416660f378
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389555B2
反応ノート
読み込み中…