Acetic Acid → HCID 86651312、化合物

HRID 1942389ノート

反応式

HRID 1942389 の反応式
C([O:3][CH:4](OCC)[CH2:5][CH2:6][CH2:7][NH:8][C:9]([N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:13][CH2:12]1)=[O:10])C.C(O)(=O)C.Cl>C(O)C>[O:3]=[CH:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([N:11]1[CH2:12][CH2:13][CH:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:15][CH2:16]1)=[O:10]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 66937642N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide

生成物 1

HCID 86651312HCID 86651312、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1.39 g (4 mmol) N-(4,4-diethoxybutyl)-4-phenylpiperidine-1-carboxamide, 5 mL acetic acid, 2.5 mL 1N aqueous hydrochloric acid and 20 mL ethanol are put together and stirred for 16 hours under argon atmosphere. Ethanol is evaporated. Then the resulting residue is dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase is dried with sodium sulfate and the solvent evaporated in vacuum. The crude product is obtained in almost quantitative yield.

後処理

  1. customEthanol is evaporated
  2. additionThen the resulting residue is dispersed in dichloromethane
  3. extractionextracted with saturated sodium bicarbonate solution
  4. dry with materialThe organic phase is dried with sodium sulfate
  5. customthe solvent evaporated in vacuum

出典と根拠

ORDレコード
ord-d24f9ad5c7b0436da7518018cb1282b0
出典データセット
uspto-grants-2013_03
特許番号
US08389555B2

反応ノート

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