Methyl 4-Formylbenzoate → 4-{[Propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]methyl}benzoic acid methylester

反応式

[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=O)=[CH:6][CH:5]=1.[CH2:13]([NH:16][CH:17]1[CH2:25][CH2:24][C:20]2[N:21]=[CH:22][S:23][C:19]=2[CH2:18]1)[CH2:14][CH3:15]>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][N:16]([CH2:13][CH2:14][CH3:15])[CH:17]2[CH2:25][CH2:24][C:20]3[N:21]=[CH:22][S:23][C:19]=3[CH2:18]2)=[CH:6][CH:5]=1

参加物

反応物 2

HCID 15294Methyl 4-Formylbenzoate

HCID 18705889Propyl-(4,5,6,7-tetrahydro-benzothiazol-6-yl)-amine

生成物 1

HCID 866513134-{[Propyl-(4,5,6,7-tetrahydrobenzothiazol-6-yl)amino]methyl}benzoic acid methylester収率 74%

実験手順

42A is prepared from 4-formyl-benzoic acid methyl ester and 1C as described for 1.

出典と根拠

ORDレコード: ord-8f64928e2ebd4cf497fa69e51dc925a1
出典データセット: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08389555B2

反応ノート

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