Acetic Acid → Phenoxyacetaldehyde

HRID 1942441

反応式

HRID 1942441 の反応式
C([O:3][CH:4](OCC)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(O)(=O)C.Cl>C(O)C>[O:6]([CH2:5][CH:4]=[O:3])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 96328(2,2-Diethoxyethoxy)benzene

生成物 1

HCID 75033Phenoxyacetaldehyde

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.84 g (4 mmol) of 69A, 5 mL of acetic acid, 2.5 mL of 1N aqueous hydrochloric acid and 20 mL of ethanol were mixed and heated under reflux under an argon atmosphere for 3 hours. Ethanol was evaporated. Then the resulting residue was dispersed in dichloromethane and extracted with saturated sodium bicarbonate solution. The organic phase was dried with sodium sulfate and the solvent evaporated in vacuum. The crude product was obtained in almost quantitative yield.

後処理

  1. temperatureheated
  2. temperatureunder reflux under an argon atmosphere for 3 hours
  3. customEthanol was evaporated
  4. additionThen the resulting residue was dispersed in dichloromethane
  5. extractionextracted with saturated sodium bicarbonate solution
  6. dry with materialThe organic phase was dried with sodium sulfate
  7. customthe solvent evaporated in vacuum

出典と根拠

ORDレコード
ord-2ec187ccb9594cdb8a00a7050c53f9f6
出典データセット
uspto-grants-2013_03
特許番号
US08389555B2

関連ノート

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