Diisopropylamine → HCID 66704174、化合物

HRID 1943010ノート

反応式

HRID 1943010 の反応式
[O:1]=[C:2]1[C@@:6]([N:12]2[CH:16]=[CH:15][CH:14]=[CH:13]2)([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][C:4](=[O:17])[NH:3]1.[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].CCCCCC>C(OCC)(=O)C>[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].[O:1]=[C:2]1[C@@:6]([N:12]2[CH:13]=[CH:14][CH:15]=[CH:16]2)([C:7]([O:9][CH2:10][CH3:11])=[O:8])[CH2:5][C:4](=[O:17])[NH:3]1

参加物

5

反応物 3

HCID 7912DiisopropylamineHCID 8058HexaneHCID 10823690Ethyl (3R)-2,5-dioxo-3-(1H-pyrrol-1-yl)-3-pyrrolidinecarboxylate

生成物 1

HCID 66704174HCID 66704174、化合物収率 60%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
40 °C

実験手順

Ethyl (R)-2,5-dioxo-3-(pyrrol-1-yl)pyrrolidine-3-carboxylate (220 mg) was dissolved in ethyl acetate (1 ml) and thereto was added diisopropylamine (0.130 ml). To this solution was added hexane (1 ml) and the resulting white suspension was warmed at 40° C. to give a homogeneous solution. This mixture was allowed to stand at room temperature and precipitated crystal was collected by filtering to give ethyl (R)-2,5-dioxo-3-(pyrrol-1-yl)pyrrolidine-3-carboxylate diisopropylamine salt (198 mg, 60%) as crystal.

後処理

  1. customto give a homogeneous solution
  2. customto stand at room temperature
  3. customprecipitated crystal
  4. customwas collected
  5. filtrationby filtering

出典と根拠

ORDレコード
ord-095727a490014f0ab45ac4d8c621cf1d
出典データセット
uspto-grants-2013_03
特許番号
US08389742B2

反応ノート

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