6,7-dihydro-5H-cyclopenta[c]pyridin-3-ylmethanol → 6,7-Dihydro-5H-cyclopenta[c]pyridine-3-carbaldehyde

HRID 1943163ノート

反応式

HRID 1943163 の反応式
[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[CH:4]=[C:3]([CH2:10][OH:11])[N:2]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[CH:4]=[C:3]([CH:10]=[O:11])[N:2]=1

参加物

4

反応物 1

HCID 685981886,7-dihydro-5H-cyclopenta[c]pyridin-3-ylmethanol

生成物 1

HCID 866420966,7-Dihydro-5H-cyclopenta[c]pyridine-3-carbaldehyde収率 59%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 6,7-dihydro-5H-cyclopenta[c]pyridin-3-ylmethanol (189 mg, 1.267 mmol) in DCM (10 ml) at rt under argon was treated with manganese dioxide (1.101 g, 12.67 mmol) and then stirred at rt for 2 h, filtered through a thin pad of Kieselguhr, eluting with DCM (40 ml), the organic extracts were evaporated to give the crude product as a brown oil (110 mg, 59%).

後処理

  1. filtrationfiltered through a thin pad of Kieselguhr
  2. washeluting with DCM (40 ml)
  3. customthe organic extracts were evaporated

出典と根拠

ORDレコード
ord-bfcae35bf4a748bb8a612d5e200ca65a
出典データセット
uspto-grants-2013_03
特許番号
US08389524B2

反応ノート

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