HCID 68598110、化合物 → 1,3-Dihydrofuro[3,4-c]pyridine-6-carbaldehyde
反応式
[CH2:1]1[C:9]2[CH:8]=[C:7]([CH2:10][OH:11])[N:6]=[CH:5][C:4]=2[CH2:3][O:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]1[C:9]2[CH:8]=[C:7]([CH:10]=[O:11])[N:6]=[CH:5][C:4]=2[CH2:3][O:2]1参加物
4
実験手順
A solution of 1,3-dihydrofuro[3,4-c]pyridin-6-ylmethanol (66 mg, 0.437 mmol) in DCM (5 ml) at rt under argon was treated with manganese dioxide (380 mg, 4.37 mmol) and then stirred at rt for 2 h, filtered through a thin pad of Kieselguhr, eluting with DCM (40 ml) and methanol (10 ml), the organic extracts were evaporated to give the crude product as a brown oil (65 mg, 100%)
後処理
- filtrationfiltered through a thin pad of Kieselguhr
- washeluting with DCM (40 ml) and methanol (10 ml)
- customthe organic extracts were evaporated
出典と根拠
- ORDレコード
- ord-0cb9b937154b488a8d412fdf17e4cf57
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389524B2
反応ノート
読み込み中…