Dichloromethane → HCID 86642113、化合物
反応式
[F:1][C:2]([F:20])([F:19])[C:3]([NH:5][CH2:6][C@@H:7]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8]1)=[O:4].C(Cl)[Cl:22]>O1CCOCC1>[ClH:22].[F:20][C:2]([F:1])([F:19])[C:3]([NH:5][CH2:6][C@@H:7]1[CH2:11][CH2:10][NH:9][CH2:8]1)=[O:4]参加物
4
実験手順
To a 100 mL round-bottomed flask was added 1,1-dimethylethyl (3S)-3-{[(trifluoroacetyl)amino]methyl}-1-pyrrolidinecarboxylate (830 mg, 2.80 mmol) in DCM (25 ml) at 25° C. to give a colorless solution. 4N HCl (3.50 ml, 14.01 mmol) in dioxane was added and the reaction was allowed to stir o/n. The reaction was concentrated under vacuum to give the desired compound as colorless oil which was used in the next reaction without further purification. Isolated 2,2,2-trifluoro-N-[(3R)-3-pyrrolidinylmethyl]acetamide (550 mg, 2.364 mmol, 84% yield).
後処理
- customto give a colorless solution
- concentrationThe reaction was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-582860d9ee8b4e58b443f08d9354b55b
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389524B2
反応ノート
読み込み中…