2-Bromoethanol → 2-Oxo-1,3-oxazolidine-3-sulfonyl chloride
反応式
Br[CH2:2][CH2:3][OH:4].[Cl:5][S:6]([N:9]=[C:10]=[O:11])(=[O:8])=[O:7]>ClCCl>[O:11]=[C:10]1[N:9]([S:6]([Cl:5])(=[O:8])=[O:7])[CH2:2][CH2:3][O:4]1参加物
4
実験手順
A solution of 1.13 ml of 2-bromoethanol (15.9 mmol, 1.0 eq) in dichloromethane (20 ml) was slowly added to a solution of 2.25 g of chlorosulfonyl isocyanate (15.9 mmol, 1.0 eq) in dichloromethane (100 ml) under argon at 0° C. in such a way that the temperature did not exceed 10° C. After the addition was complete, stirring was continued at 0° C. for 30 min. The product obtained in this way was directly reacted further in the next step.
後処理
- customdid not exceed 10° C
- additionAfter the addition
- customThe product obtained in this way
- customwas directly reacted further in the next step
出典と根拠
- ORDレコード
- ord-43ac4355e5da4b9ca373b80ca80f8d56
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08389764B2
反応ノート
読み込み中…