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HRID 1943463作成日：2026年10月27日
6-chloro-N-(3-fluoropyridin-4-yl)-8-(isoxazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide → HCID 178522303、化合物
https://huagongshe.com/reaction/1943463
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 6-chloro-N-(3-fluoropyridin-4-yl)-8-(isoxazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide | HCID 59624780 | — |
| 反応物 | HCID 178511715 | HCID 178511715 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | HCID 178522303 | HCID 178522303 | 61.4% |
反応手順
A mixture of 6-chloro-N-(3-fluoropyridin-4-yl)-8-(isoxazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamide (20 mg, 0.054 mmol) and (trans)-4-aminocyclohexanol (61.6 mg, 0.535 mmol) in NMP (0.4 mL) was heated at 110° C. overnight. The reaction mixture was cooled to room temperature, and purified by reversed-phase preparative HPLC. The desired fractions were concentrated and dried to give 15 mg the title compound as a beige solid. HPLC Rt=2.615 min (Chromolith SpeedROD 4.6×50 mm, 10-90% aqueous methanol containing 0.1% TFA, 4 min gradient, monitored at 220 nm), [M+1]=453.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08389527B2 |
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| 出典データセット | uspto-grants-2013_03 |
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| ORD ID | ord-be5a1e2d52d744679539ac168f213b6b |
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| 出典メモ | uspto-grants-2013_03 |
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