化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 4-(p-Iodophenyl)butyric acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | 4-(4-Aminophenyl)butanoic acid | HCID 27049 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 生成物 | 4-(p-Iodophenyl)butyric acid | HCID 4645427 | — |
反応手順
A 5 C mixture of 4-(4-aminophenyl)butyric acid (1.0 eq) and aqueous 6N hydrochloric acid (5.44 eq) was treated with 1.05 eq of a 3N aqueous solution of sodium nitrite, adding slowly so as to keep the temperature below 5 C. A solution of 2.8N aqueous potassium iodide (1.01 eq) was added. The reaction was stirred overnight. The layers were separated. The organic phase was purified by flash chromatography using methanol/methylene chloride as eluant to give 4-(4-iodophenyl)butyric acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07744910B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b1722475e6454080a4154f9c9988b203 |
| 出典メモ | uspto-grants-2010_06 |