Hydrochloric Acid → HCID 66599737、化合物
反応式
[OH:1][CH:2]([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:21]([NH:23][C:24]2[CH:25]=[C:26]3[C:31](=[CH:32][CH:33]=2)[CH:30]=[N:29][CH:28]=[CH:27]3)=[O:22])[CH2:12][NH:13]C(=O)OC(C)(C)C)=[CH:7][CH:6]=1.[ClH:40]>C(Cl)Cl>[ClH:40].[ClH:40].[NH2:13][CH2:12][CH:11]([C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH:2]([OH:1])[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[CH:6][CH:7]=1)[C:21]([NH:23][C:24]1[CH:25]=[C:26]2[C:31](=[CH:32][CH:33]=1)[CH:30]=[N:29][CH:28]=[CH:27]2)=[O:22]参加物
4
実験手順
To tert-butyl 2-(4-(2-hydroxy-2-phenylethoxy)phenyl)-3-(isoquinolin-6-ylamino)-3-oxopropylcarbamate (E276) in CH2Cl2 was added HCl (4 N, dioxane) and the solution was stirred overnight. The solvents were evaporated to give 3-amino-2-(4-(2-hydroxy-2-phenylethoxy)phenyl)-N-(isoquinolin-6-yl)propanamide dihydrochloride (E278).
後処理
- customThe solvents were evaporated