1H-Imidazole, 2-(1-methylethyl)- → {8-Chloro-2-difluoromethoxy-3-[4-(2-isopropylimidazol-1-yl)benzyl]-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester

HRID 1944362

反応式

HRID 1944362 の反応式
[C:1]([O:5][C:6](=[O:41])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:40])=[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28](B3OC(C)(C)C(C)(C)O3)=[CH:27][CH:26]=1)[C:13]([O:20][CH:21]([F:23])[F:22])=[N:14]2)([CH3:4])([CH3:3])[CH3:2].[CH:42]([C:45]1[NH:46][CH:47]=[CH:48][N:49]=1)([CH3:44])[CH3:43]>>[C:1]([O:5][C:6](=[O:41])[CH2:7][O:8][C:9]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]2[C:10]=1[C:11]([CH3:40])=[C:12]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([N:46]3[CH:47]=[CH:48][N:49]=[C:45]3[CH:42]([CH3:44])[CH3:43])=[CH:27][CH:26]=1)[C:13]([O:20][CH:21]([F:23])[F:22])=[N:14]2)([CH3:3])([CH3:4])[CH3:2]

参加物

3

反応物 2

HCID 1234571H-Imidazole, 2-(1-methylethyl)-HCID 67458465{8-Chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester

生成物 1

HCID 67456320{8-Chloro-2-difluoromethoxy-3-[4-(2-isopropylimidazol-1-yl)benzyl]-4-methylquinolin-5-yloxy}acetic acid tert-butyl ester

実験手順

The title compound was prepared by the method of Preparation 18a using {8-chloro-2-difluoromethoxy-4-methyl-3-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzyl]quinolin-5-yloxy}acetic acid tert-butyl ester and 2-isopropyl-1H-imidazole.

出典と根拠

ORDレコード
ord-ffac1efc56f04e5eaa143ffc42ea9236
出典データセット
uspto-grants-2013_03
特許番号
US08394830B2

関連ノート

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