Potassium Carbonate → 3-(Thiophen-2-ylsulfanyl)thiophene-2-carbaldehyde

HRID 1944408ノート

反応式

HRID 1944408 の反応式
Cl[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8].C(=O)([O-])[O-].[K+].[K+].[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[SH:20]>CN(C)C=O>[S:15]1[CH:19]=[CH:18][CH:17]=[C:16]1[S:20][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 5226742-ThiophenethiolHCID 27358253-Chlorothiophene-2-carbaldehyde

生成物 1

HCID 866521863-(Thiophen-2-ylsulfanyl)thiophene-2-carbaldehyde収率 97.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 3-chlorothiophene-2-carbaldehyde (1.0 g), potassium carbonate (2.8 g) and N,N-dimethylformamide (6.8 mL) was treated dropwise with thiophene-2-thiol (0.87 g), and the resulting mixture was stirred at room temperature for 3 hours. The mixture was poured onto water (150 mL) and extracted with diethyl ether. The combined organic extract was washed with saturated aqueous sodium hydrogen carbonate solution and saturated aqueous sodium chloride solution, and then dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a red oil (1.5 g).

後処理

  1. additionThe mixture was poured onto water (150 mL)
  2. extractionextracted with diethyl ether
  3. extractionThe combined organic extract
  4. washwas washed with saturated aqueous sodium hydrogen carbonate solution and saturated aqueous sodium chloride solution
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-f69c132f935243e8b4ad23356c78f40f
出典データセット
uspto-grants-2013_03
特許番号
US08394836B2

反応ノート

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