Dimethyl Sulfoxide → 3-(Pyridine-3-sulfonyl)thiophene-2-carbaldehyde

HRID 1944434ノート

反応式

HRID 1944434 の反応式
Cl[C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]=[O:8].[Na+].[N:10]1[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([O-:18])=[O:17])[CH:11]=1.CS(C)=O>O>[N:10]1[CH:15]=[CH:14][CH:13]=[C:12]([S:16]([C:2]2[CH:6]=[CH:5][S:4][C:3]=2[CH:7]=[O:8])(=[O:18])=[O:17])[CH:11]=1

参加物

5

反応物 3

HCID 679Dimethyl SulfoxideHCID 27358253-Chlorothiophene-2-carbaldehydeHCID 23697071Sodium pyridine-3-sulfinate

生成物 1

HCID 866521933-(Pyridine-3-sulfonyl)thiophene-2-carbaldehyde収率 28.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

A mixture of 3-chlorothiophene-2-carbaldehyde (0.16 g), pyridine-3-sulfinic acid sodium salt (0.30 g) and dimethyl sulfoxide (2.0 mL) was heated at 80° C. for 3 hours and then at 90° C. for 3 hours. The mixture was diluted with water, extracted with ethyl acetate and the combined organic extract was dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a grey solid (0.079 g).

後処理

  1. extractionextracted with ethyl acetate
  2. extractionthe combined organic extract
  3. dry with materialwas dried over magnesium sulfate
  4. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-0017927d9ad14a2eb52085da64a7ee85
出典データセット
uspto-grants-2013_03
特許番号
US08394836B2

反応ノート

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