Benzenesulfinic acid, sodium salt → 4-Benzenesulfonylthiazole-5-carbaldehyde

HRID 1944481ノート

反応式

HRID 1944481 の反応式
Cl[C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH:7]=[O:8].[Na+].[C:10]1([S:16]([O-:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CS(C)=O>[C:10]1([S:16]([C:2]2[N:3]=[CH:4][S:5][C:6]=2[CH:7]=[O:8])(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 2723840Benzenesulfinic acid, sodium saltHCID 145013174-Chloro-1,3-thiazole-5-carbaldehyde

生成物 1

HCID 866522084-Benzenesulfonylthiazole-5-carbaldehyde収率 89.3%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4-chlorothiazole-5-carbaldehyde (0.15 g), benzenesulfinic acid sodium salt (0.25 g) and dimethyl sulfoxide (7.0 mL) was stirred at 100° C. for 30 minutes. The mixture was cooled to room temperature, poured onto ice/water (50 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated aqueous sodium chloride solution and dried over magnesium sulfate. The solvent was removed under reduced pressure to afford the title compound as a tan oil (0.23 g).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. additionpoured onto ice/water (50 mL)
  3. extractionextracted with ethyl acetate
  4. extractionThe combined organic extract
  5. washwas washed with saturated aqueous sodium chloride solution
  6. dry with materialdried over magnesium sulfate
  7. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-2a6ec8581a2b4a66bf1d7500efc21129
出典データセット
uspto-grants-2013_03
特許番号
US08394836B2

反応ノート

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